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Patient Education · Cornea

Neurotrophic Keratitis

Neurotrophic keratitis (NK) happens when the cornea’s nerves stop working well. Without them, the surface can’t heal properly, even though the eye may not hurt.

What it isPoor healing from reduced corneal nerve function
Common causesShingles or herpes, diabetes, and prior eye or brain surgery
HallmarkA sore that won’t heal, often with little pain
TreatmentFrom protective drops to nerve growth factor and surgery

Why the nerves matter

The cornea has more nerve endings than almost any part of the body. Besides sensing touch and pain, these nerves tell you to blink, keep tears flowing, and release signals the surface needs to repair itself.

When the nerves are damaged, the surface slowly breaks down and small injuries don’t heal. Because the cornea has lost feeling, this often happens quietly, without the pain that would normally send someone to the doctor.

An eye with a smooth, oval, shallow sore in the center of the cornea under normal lightNormal light
The same eye under blue light with dye: the central oval sore glows bright greenBlue light & dye
The classic sore of NK is a horizontal oval in the center of the cornea, with rolled, slightly uneven edges. It is hard to see in normal light; a yellow-green dye under blue light makes it glow, and in NK it can linger for weeks.

Three stages

  1. 1

    A rough surface

    The surface becomes irregular and dull, with dryness and blur.

  2. 2

    A sore that won’t heal

    An open area with rolled edges, called a persistent epithelial defect, lasts two weeks or more.

  3. 3

    Ulcer & thinning

    The cornea can thin, scar, or even develop a hole, which needs urgent care.

How it can be treated

Protect the surface

Preservative-free lubricants, and stopping any drops that may be irritating the eye.

Shield while it heals

A bandage contact lens or a thin amniotic membrane covers the sore so new cells can grow.

Healing drops

Serum tears made from your own blood, and a prescription nerve growth factor drop, can help the cornea repair itself.

Partial eyelid closure

Temporarily closing part of the eyelid protects the cornea and helps stubborn sores heal.

Advanced surgery

For severe cases, procedures can repair thinning or, in select cases, route a healthy nerve to the cornea.

Treat the cause

Managing diabetes, herpes, or shingles helps prevent further nerve damage.

Who is at risk?

  • Shingles or herpes infection of the eye
  • Diabetes
  • Previous eye surgery, injury, or long-term use of certain drops
  • Brain surgery or conditions affecting the facial nerves
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General information only, not medical advice. Your doctor will recommend what fits your eyes.

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