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Patient Education · Cornea

Fuchs’ Dystrophy

Fuchs’ dystrophy is an inherited condition in which the cornea’s inner pump cells slowly wear out. The cornea swells and vision turns foggy, and today it is very treatable.

What it isSlow loss of the cornea’s inner pump cells
Who it affectsUsually adults over 50, often with a family history
Classic signFoggy vision that is worst in the morning
TreatmentSalt drops early, and DMEK when vision suffers

What happens in Fuchs’

The innermost layer of the cornea, the endothelium, is a single sheet of cells that constantly pumps fluid out so the cornea stays thin and clear. These cells do not grow back.

In Fuchs’ dystrophy, small spots called guttae appear on the inner surface where pump cells have been lost, and the remaining cells gradually thin out. When too few remain, fluid builds up, the cornea swells, and vision turns hazy.

With your eyes closed overnight, less moisture evaporates from the surface, so blur is often worst on waking and clears as the day goes on.

Cutaway of the cornea seen from below: the single layer of pump cells has scattered dark, empty patches where cells are missing, and the middle layer is swollen and hazy
In Fuchs’, patchy spots with no pump cells (guttae) spread across the inner surface, and the cornea swells.

How it progresses

  1. 1

    Early

    Spots of missing cells (guttae) are seen during an eye exam, often years before any symptoms.

  2. 2

    Middle

    Morning blur, glare and halos around lights, and colors or contrast that seem washed out.

  3. 3

    Advanced

    Blur that lasts all day. Tiny blisters can form on the surface and break, which can be painful.

Simulated view with corneal disease Simulated healthy vision Healthy vision With corneal disease
Race day through a swollen cornea, as in Fuchs’ dystrophy: haze, ghosting, and glare. Drag to compare. Simulation for illustration only.

How it can be treated

Salt drops & ointment

Hypertonic (5% sodium chloride) drops and ointment draw fluid out of the cornea and can ease morning blur in earlier stages.

Gentle airflow

Some people hold a hair dryer at arm’s length, on a cool setting, toward the open eyes in the morning to help the extra fluid evaporate.

DMEK

When vision suffers, DMEK replaces only the failed inner layers with healthy donor tissue. It is the most effective treatment for Fuchs’ today.

Learn about DMEK

Fuchs’ and cataracts

Fuchs’ and cataracts often show up around the same age. Cataract surgery can put extra stress on the pump cells, so planning matters. When both are present, cataract surgery and DMEK can often be done together in one visit, or in the order that best protects your vision.

Specialty Focus DMEK: transplanting only the layers that failed For Fuchs’ dystrophy, DMEK replaces just the cornea’s thin inner layers. It is a focus of Dr. Tenkman’s practice. Learn about DMEK
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General information only, not medical advice. Your doctor will recommend what fits your eyes.

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